RAGE receptors in membrane, illustration

Numéro d’image : 13956852
RAGE receptors in membrane, illustration
Illustration of a receptor for advanced glycation endproducts (RAGE) within a lipid bilayer membrane. Above the membrane, the receptor's V, C1 and C2 domains are blue, green and orange, respectively. This transmembrane protein belongs to the immunoglobulin superfamily and is able to bind to multiple molecules. Binding results in a signal cascade that causes pro-inflammatory gene activation. The expression of RAGE is stimulated by cellular stresses, such as inflammation, and so this leads to a positive feedback cycle that results in chronic inflammation. RAGE is involved in the pathogenesis of a number of diseases including diabetes, Alzheimer's disease and cancers.
Licence : Libre de droits
Crédit: Science Photo Library / THOM LEACH
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