Activin A receptor type I protein, molecular model
Numéro d’image : 13505008
| Molecular model of the cytoplasmic domain of the activin A receptor type I (ACVR1) protein (white, blue and yellow) bound to its natural inhibitor FK506-binding protein 12 (FKB12, purple ribbon) and the synthetic inhibitor RK-71807 (spheres). ACVR1 plays a role in the bone morphogenic protein (BMP) pathway. A mutant form of the protein is responsible for the rare genetic disease fibrodysplasia ossificans progressiva (FOP). FOP is a disease where fibrous tissues, including muscle, tendons and ligaments, are gradually replaced by bone (ossified). The mutation in ACVR1 decreases its affinity for FKB12, leading to increased activity of the protein and therefore increased production of bone. | |
| Licence : | Droits gérés |
| Crédit: | Science Photo Library / Andrade, Ramon / 3dciencia |
| Taille de l’image : | 4827 px × 3620 px |
| Model Release : | Non requis |
| Property Release : | Non requis |
| Restrictions : | - |
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