Haemangioblastoma, light micrograph

Numéro d’image : 13296461
Haemangioblastoma, light micrograph
Haemangioblastoma, light micrograph. Hemangioblastoma is a WHO Grade I tumour that may occur sporadically or in the setting of von Hippel Lindau disease (about 25% of patients). The peak incidence is seen in the 3rd and 4th decades. The most common location is cerebellum. On MRI with contrast, the tumour usually appears a sharply demarcated enhancing mass with cystic areas in the cerebellum. This appearance is seen in about 60% of cases; remaining 40% of cases are entirely solid. About 10-25% of patients with hemangioblastoma carry a germline mutation in the VHL gene. Grossly, hemangioblastomas are generally well circumscribed with solid and cystic components. They are usually dark red-brown given extensive vascularity. Microscopically, the two main components of hemagioblastoma are prominent capillary vasculature surrounded by stromal cells with vacuolated or lightly eosinophilic cytoplasm. In this case, the stromal cells have epithelioid appearance with some resemblance to renal cell carcinoma.
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Crédit: Science Photo Library / WEBPATHOLOGY
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