Insulin resistance and diabetes,illustration

Numéro d’image : 12897034
Insulin resistance and diabetes,illustration
Diabetes caused by insulin resistance,illustration. Insulin resistance (IR) is a pathological condition where cells cannot respond normally to the hormone insulin (orange). Affected cells produce fewer insulin receptors (blue),and lack the ability to recognise the binding of insulin (right). Insulin binding would normally activate the glucose transporter proteins (through a signal transduction pathway) allowing for the transport of glucose into the cell (left). This means that patients affected by insulin resistance have increased blood sugar levels (hyperglycaemia) because glucose is not transported from the blood into cells efficiently. Insulin resistance is therefore the driving cause of type 2 diabetes.
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Crédit: Science Photo Library / Gaertner, Juan
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