False-colour transmission electron micrograph (TEM) of a human white blood cell (bottom),showing presence of an HLA antigen (human leucocyte antigen),which appears as uneven red areas on exterior suface of the cell. The HLA antigens arise from a gene cluster on chromosome 6 in humans,which is referred to as the Major Histocompatability Complex (MHC). This title arose through studies on graft rejection in mice,where matched groups of antigens in donor & recipient animals markedly improved graft survival. In addition,it is now recognized that HLA antigens are involved in many other immunological processes. Magnification: X 8,800 at 35mm size | |
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