Light micrograph of a biopsy section through the human cervix revealing carcinoma-in-situ (severe dysplasia,CIN 3). The cervix is lined by a stratified squamous epithelium. Normally,all cell division is confined to the basal epithelial layer (centre of image). As a cell matures & rises up the layers,its cytoplasm expands & nucleus shrinks in size - a normal superficial cell is flat,with a small nucleus & a large cytoplasm. In carcinoma-in-situ the gradual stratification in cell maturation seen in normal epithelium is absent: dysplastic (abnormal) cells extend throughout the entire epithelium. The basement membrane remains defined & intact | |
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Crédit: | Science Photo Library |
Taille de l’image : | 5047 px × 3543 px |
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