Dr Gerard Evan,British molecular biologist and expert on apoptosis,the genetically-programmed tendency of cells to die. Evan works at the Imperial Cancer Research Fund,London,on a gene called c- myc,which is thought to act as a switch for apoptosis. If the gene is activated,the cell proliferates; if not,the cell dies. Evan has shown that the activity of c-myc is under dual control by cytokines. One group of cytokines turns cell growth on,but at the same time prompts apoptosis. A second type,called IGF-1,overrides the apoptosis prompt of the first group. Many cancerous cells have mutated c-myc,which are thus immune from IGF-1. Photographed in 1994 | |
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