DNA repair enzyme. Computer simulation of a HAP1 (lower right,also called APE/Ref-1) enzyme repairing a damaged Deoxyribonucleic Acid (DNA,upper left) molecule. HAP1 is coloured to show the alpha helices (blue) and beta strands (red) of its structure. DNA carries a cell's genetic code. The DNA in each cell is damaged 2000-10,000 times a day by hydrolysis reactions which convert N- glycosyl bonds into apurinic/apyrimidinic fractures. DNA damage can cause cell death or cancer. HAP1 is the first protein to recognise the damage & starts repairs by breaking the DNA's molecular backbone so that other proteins can replace the faulty section | |
Licence : | Droits gérés |
Crédit: | Science Photo Library / King-Holmes, James |
Taille de l’image : | 3852 px × 3803 px |
Model Release : | Non requis |
Property Release : | Non requis |
Restrictions : | - |