This video showcases the progression of an atherosclerotic plaque rupture. Atherosclerosis is a disease that causes a blood vessel to narrow because of plaque build-up. This plaque can become a lesion after lipids (fatty material) accumulate in a specific location and a fibrous cap develops. That lesion has the possibility of bursting, causing a plaque rupture. Here the camera closes in on a sectioned artery with red and white bloods cells shown flowing within. The amount of plaque (yellow) on the arterial walls grows larger and develops its fibrous cap (white). The lesion then ruptures, sending the plaque and fibrous material into the bloodstream. Heart attack or stroke can result. Thrombosis (blood clotting) can occur before of after a plaque rupture.