Type III hypersensitivity in a blood vessel, animation. Also known as immune-complex disease, this is an inflammatory response that results from an excess of soluble antigen (grey spheres). Antibodies (y-shaped) bind the antigens to form immune complexes. These complexes are bound by the complement protein C1Q (red and yellow) to form C1-complexes. This activates the complement system, producing the anaphylatoxins C3a and C5a. The anaphylatoxins cause the release of histamine from basophil cells (orange), induce the aggregation (clotting) of platelets (yellow), and recruit inflammatory cells, such as neutrophils (grey) to the site. The histamines and enzymes released by the neutrophils cause tissue damage and increased vascular permeability | |
Licence : | Droits gérés |
Crédit : | Science Photo Library / Biocosmos / Francis Leroy & Marie Martinache |
Model Release : | Non requis |
Durée : | 32 Secondes |
Aspect ratio : | 16/9 |
Restrictions : | - |