Cellular basis of cyanide poisoning

Référence de la vidéo 11937606
Cellular basis of cyanide poisoning. Animation showing the mechanism by which respiratory poisons such as cyanide cause death. They act by blocking the electron transport chain at various points. Here, the effect of cyanide is shown on cell organelles called mitochondria (one at bottom left). Mitochondria produce and store energy obtained in respiration, with energy transferred along electron transport chains. The inner mitochondrial membrane is shown with embedded proteins and complexes. The electron transport chain shown here starts with a reduced form of nicotinamide adenine dinucleotide (NADH2, top left). The electrons (blue) are transferred to NADH dehydrogenase (orange), with two protons (green) moving from inside to outside the mitochondrion (matrix to intermembrane space). The next stage is transfer of the electrons to the cytochrome b-c1 complex (red), with further transfer of an electron to cytochrome oxidase (green). It is this latter complex that is acted on by cyanide (white flash). Death results from cyanide poisoning because cytochrome oxidase is irreversibly inhibited and can no longer transfer electrons onwards to molecular oxygen (O2, top right). This in turn prevents the functioning of proton pumps (bottom right) and the synthesis of ATP (adenosine triphosphate). Adenosine diphosphate (ADP) and inorganic phosphate (Pi), part of the same process, are also shown. For this animation with labels, see K004/3513.
Licence : Droits gérés
Crédit : Science Photo Library / Biocosmos / Francis Leroy & Edwin Vandermeeren
Model Release : Non requis
Durée : 40 Secondes
Aspect ratio : 16/9
Restrictions : -

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