Illustration based on the X-ray structure of the human NOVA2 RNA-binding domain (grey) in complex with a synthetic RNA (ribonucleic acid) oligonucleotide (red). NOVA (neuro-oncological ventral antigen) proteins play an important role in neuronal (nerve cell) development and in the adult brain. By binding to mRNA (messenger RNA) they regulate a process, alternative splicing, that generates protein variants with different functions from a single gene. These variants are needed at different times and locations during development. Mutations in NOVA2 lead to neurodevelopmental and intellectual disabilities. | |
Licence : | Droits gérés |
Crédit: | Science Photo Library / FRANCISCO J. ENGUITA |
Taille de l’image : | 4528 px × 4556 px |
Model Release : | Non requis |
Property Release : | Non requis |
Restrictions : | - |