GABA-B receptor binding to baclofen, molecular model

Numéro d’image : 13436191
GABA-B receptor binding to baclofen, molecular model
Molecular model of baclofen (red) binding to gamma-aminobutyric acid receptor B (GABA-B receptor, blue-purple), an example of a G-coupled protein receptor (GPCR), and triggering a signal cascade. GABA-B receptors are found in the central nervous system and parts of the peripheral nervous system. They are crucial for opening potassium ion channels and reducing adenyl cyclase activity. Binding of the drug baclofen to GABA-B causes the alpha subunit (light blue) of the G-protein to exchange its bound molecule of GDP (guanosine diphosphate) for a molecule of GTP (guanosine triphosphate). This releases the alpha subunit from the GABA-B receptor allowing it to bind to the enzyme adenylyl cyclase (blue) and activate it. Adenylyl cyclase catalyses the conversion of ATP (adenosine triphosphate) to cyclic adenosine monophosphate (cAMP). cAMP regulates numerous cell functions.
Licence : Libre de droits
Crédit: Science Photo Library / Gaertner, Juan
Model Release : Non requis
Property Release : Non requis
Restrictions : -

Prix pour cette image À partir de 29 €

Pour une utilisation numérique (72 dpi) À partir de 29 €
Pour un usage d'impression (300 dpi) À partir de 325 €

Mots clés

;