Animation of red blood cells in a blood vessel, showing the surface antigens (blue) that determine the blood type, with an antibody (orange) binding to one of them. An individual's blood type is based on the antigens found on the surface of their red blood cells. There are two main types, called A antigens and B antigens. An individual's cells can have one, both or none of these two types, giving them blood type A or B, AB or O respectively. People with A antigens (blood type A) have antibodies in their blood that target B antigens, called anti-B antibodies. Type B people have anti-A antibodies. It is these antibodies that bind to antigens and cause an adverse reaction if people receive the wrong type of blood. Type AB people have no antibodies in their blood, and can receive blood from a donor of any type. People with type O blood have no antigens, and can donate the cells to people of any blood type.
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